Brittany Butts
  • Butts Research
    • Meet the Team
    • Metabolomic Pathways of Symptoms in Black Adults with Heart Failure
    • Skeletal Muscle in Heart Failure with Preserved Ejection Fraction
    • Inflammasome in Heart Failure
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    • Telomeres in Heart Failure
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​The CARDI Study:
Cognitive Function, Alzheimer’s Disease Risk, Social Determinants of Health, and Immune Function in Persons with Cardiovascular Disease

What is the CARDI study?

​This observational study looks to determine the relationship between cardiovascular disease, cognition, immune function, and Alzheimer's disease risk factors during middle age. You can check out our flyer for the study here. 

Read the story behind CARDI: Treating the H
​eart, Protecting the Brain
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Who is included in the CARDI study?

This study is recruiting middle-aged adults between the ages of 40 and 70 years.

To be eligible for the study, you must meet the following criteria:
  • Are 40 years of age and older
  • Have normal cognition or minor memory problems​
  • Willing to fast for eight hours
  • Willing to complete study procedures
  • Complete eligibility phone screen and brief memory screening

​You may NOT be eligible if you meet these criteria:
  • Currently in another investigational drug study
  • Residence in a skilled nursing facility
  • Are pregnant or nursing
  • Significant neurological disease, such as stroke, TBI, or history of significant head trauma

What is involved?

If you participate in this research you will attend 1 study visit. These study visits can be anywhere from 3 to 4 hours long. Some procedures will require that you fast for 8 or more hours prior.  

You will also complete questionnaires for this research. These questionnaires will be sent to you via email to complete at home on your computer within a week of the study visit. 

Procedures that will occur at these visits include:
  • Cognitive (memory) testing
  • Medical and health related questionnaires
  • Blood samples
  • Pulse wave velocity (aka vascular ultrasound)

Why is this research important?

Mid-life cardiovascular risk factors contribute to the development of Alzheimer’s disease in later life and to Alzheimer’s disease progression. More and more middle aged adults are living with cardiovascular disease, conferring an increased risk for Alzheimer's disease and other brain-related outcomes, such as loss of memory. This study will examine the relationship between cardiovascular risk factors, immune function, markers of Alzheimer’s disease risk, and cognitive function in middle-aged adults with heart failure or cardiomyopathy.

We know that midlife hypertension is linked to Alzheimer's disease biomarkers, and middle age is the time of life when these Alzheimer's disease biomarkers begin to manifest. However this is unknown in middle-aged adults with heart failure and related cardiac disorders, a population increasing in prevalence. Findings from this study will lead to the identification of pathways that could potentially be modified by interventions with the goal of decreasing Alzheimer's disease risk.



​Study Locations

​This study is being conducted at Emory University

Emory University School of Nursing - Plaza Level
1520 Clifton Rd NE
Atlanta, GA 30329
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Funding Information


This study is funded by the BrightFocus Foundation. Learn more about BrightFocus' Alzheimer's Disease research at ​​https://www.brightfocus.org/alzheimers.
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​​​Learn more about improving heart and brain health:

For more information about the CARDI study, please fill out the form below.

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  • Butts Research
    • Meet the Team
    • Metabolomic Pathways of Symptoms in Black Adults with Heart Failure
    • Skeletal Muscle in Heart Failure with Preserved Ejection Fraction
    • Inflammasome in Heart Failure
    • Exercise and Heart Failure
    • Telomeres in Heart Failure
    • Heart Failure Research Studies
    • Publications
    • Presentation Abstracts
    • Atlanta Heart Failure Knowledge Test
  • PREVAIL Lab
    • Veterans PREVAIL >
      • Health Information Flyers
      • Veteran Resources and Outreach
  • MVP Study
  • CARDI Study
  • Past Studies
    • M-FADD HF Study >
      • M-FADD HF Research Findings
  • Health Information
    • Diabetes Prevention and Insulin
    • Alzheimer's Disease and Dementia
    • High Blood Pressure
    • High Cholesterol
    • Heart Attack
  • Pathophysiology Videos
  • Genetics Workshop (UNC)
  • Omics Workshop (SNRS 2023)
  • AHFKT